Regulatory Mechanisms in Carbohydrate Metabolism

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Regulatory Mechanisms in Carbohydrate Metabolism

Inhibition of mammalian hexokinase by glucose g-phosphate was first reported by Weil-Malherbe and Bone (1) and studied by Crane and Sols (2). An inhibition of rabbit muscle phosphofructokinase by excess adenosine triphosphate was observed by Lardy and Parks (3) and was shown to be reversed by a number of intracellular components by Passonneau and Lowry (4). Similar findings were reported on the...

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Regulatory Mechanisms in Carbohydrate Metabolism

The inhibition of glycolysis by respiration (Pasteur effect) and the inhibition of respiration by glycolysis (Crabtree effect) represent nonhormonal regulatory mechanisms of cellular metabolism. Some of the previous work on these phenomena in intact cells will be reviewed in subsequent papers (1, 2) together with a report on recent experimental work on ascites tumor cells. The difficulty of obt...

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Regulatory mechanisms in carbohydrate metabolism. III. Limiting factors in glycolysis of ascites tumor cells.

The rate of glucose utilization by cells is known to be influenced by various environmental factors. The effects of hormones, such as insulin, and of drugs, such as 2,Pdinitrophenol, on carbohydrate metabolism have received considerable attention. A vast amount of literature has accumulated on the suppression of fermentation in the presence of air. However, information on the intracellular pace...

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Mechanisms of pathogenesis in Listeria monocytogenes infection. 3. Carbohydrate metabolism.

Several enzymes and metabolites concerned with carbohydrate metabolism were examined in mice infected with Listeria monocytogenes. Liver glycogen and glucose decreased parallel to severity of infection. The concentration of glucose in the blood fell to abnormally low levels with a hypoglycemia being most evident at 72 hr. There was a significant decrease in the activity of hepatic uridine dipho...

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The effect of maternal hypothyroidism during pregnancy on carbohydrate metabolism in adulthood in rats

Introduction: Many of the diseases of adulthood are originated from the intrauterine conditions during fetal life. Because of the importance of thyroid hormones in growth and development of the fetus, the effects of maternal hypothyroidism on carbohydrate metabolism in adulthood was investigated. Methods: Pregnant rats were divided into the fetal hypothyroidism (FH) and the control (C) group...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1959

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)69674-7